The p75 neurotrophin receptor p75ntr also known as low affinity nerve growth factor belongs to the tumor necrosis factor family of receptors p75ntr is widely expressed in the nervous system during the development as well as in the neural crest population since p75ntr has been described as ubiquitously expressed and considered as a neural crest marker neural crest cells nccs . Neurotrophin 3 nt 3 promotes the survival and induces neurite outgrowth from a subset of neural crest nc and placode derived neurons we now report that this growth factor regulates the proliferation of cultured nc progenitor cells grown in a serum free . Our aim was to look at the effect of neurotrophins on neural crest migration and schwann cell precursors experiments by live imaging in special chambers suggest that a neural crest cells are . Focuses on the roles neurotrophins play in neural crest cell differentiation and in the survival of neural crest derivatives this book correlates in vitro data with results obtained from knock out mice with targeted neurotrophin or receptor deletions to determine the fidelity and usefulness of various experimental culture systems. Some evidence suggests that gradients of neurotrophins are important in regulating final innervation patterns eg 14 iii regulation of cell proliferation neurotrophins have been shown to regulate proliferation of many cell types including neural crest cells cerebellar granule cells and 02a cells eg 10 15 16
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