3 oxidative stress in neurodegeneration one of the most metabolically active organs of the body is the brain including the spinal cord comprising central nervous system cns which even at rest utilizes an estimated 20 of the total oxygen uptake. Genetic evidences in neurodegenerations and oxidative stress oxidative stress related neurodegeneration is not only caused by disturbed metal metabolism but genetic evidences suggests that persons associated with certain types of genetic mutations are more susceptible to gain neurological pathological compare to normal to those with normal . Here we review the role of mitochondrial oxidative stress in the aging process with a specific focus on neurodegenerative diseases understanding the molecular mechanisms involving mitochondria and oxidative stress in the aging and neurodegeneration may help to identify new strategies for improving the health and extending lifespan. Oxidative stress in neurodegeneration evidence suggesting that mutations acquired during ageing by mtdna contribute to physiological decline occurring with age and age related neurodegeneration therefore oxidative stress is an important factor in neurodegenerative diseases as the damage of the neurons could be due to either an increase . Mitochondrial function is vital for normal cellular processes mitochondrial damage and oxidative stress have been greatly implicated in the progression of aging along with the pathogenesis of age related neurodegenerative diseases nds such as alzheimers disease parkinsons disease huntingtons disease and amyotrophic lateral sclerosis
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